{"product_id":"nsj-v7163-20ug","title":"TNF alpha Antibody, 20 ug","description":"\u003cp\u003eTumor Necrosis Factor Alpha (TNF alpha) is a cytokine that binds to TNFRSF1A\/TNFR1 and TNFRSF1B\/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO\/SMAC mimetic in the RT4v6 bladder cancer cell line. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548313911576,"sku":"V7163-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_a3120d89-d5c4-47fe-b121-ca40bd4666fc.jpg?v=1768277202","url":"https:\/\/danabiosci.com\/products\/nsj-v7163-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}