{"product_id":"nsj-v7090ihc-7ml","title":"EMI-1 Antibody, 7 ml","description":"\u003cp\u003eEarly Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex\/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI-1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI-1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"7 ml","offer_id":51548326002968,"sku":"V7090IHC-7ML","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_5c125da3-9e7e-402f-a44d-29ebb1921ce6.jpg?v=1768277577","url":"https:\/\/danabiosci.com\/products\/nsj-v7090ihc-7ml","provider":"Dana Bioscience","version":"1.0","type":"link"}