{"product_id":"nsj-v5838-20ug","title":"SS18-SSX Antibody \/ Protein SSXT, 20 ug","description":"\u003cp\u003eS18 is a protein that has been shown to be a part of the SWI\/SNF complex. The SS18-SSX fusion proteins are a result of in-frame fusions that fuse the SS18 gene on chromosome 18 with X chromosome genes SSX1, SSX2, and to a lesser extent SSX4. Human synovial sarcoma (SS) accounts for 8-10% of all soft tissue malignancies and 95% of these malignancies express the recurrent translocation of the SS18 gene on chromosome 18. The N-terminal SNH domain (SYT N-terminal homology domain) of the SS18 protein interacts with SWI\/SNF chromatin remodeling complexes via the N terminal region of BRM and BRG1 subunits. Studies of the SS18-SSX fusion in SS suggest that endogenous SS18 competes with the mutant SS18-SSX fusion for occupancy in the SWI\/SNF complexes resulting in the displacement of SNF5 (BAF47) subunit. Displacement of the SNF5 subunit results in altered function of the SWI\/SNF complex that leads to deregulated expression of genes such as Sox2 in synovial sarcoma.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548338618648,"sku":"V5838-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_5572ae83-d4dd-409c-bc3c-916bb4a6c841.jpg?v=1768278064","url":"https:\/\/danabiosci.com\/products\/nsj-v5838-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}