{"product_id":"nsj-v5822-20ug","title":"Recombinant SIGLEC3 Antibody \/ Sialic acid-binding Ig-like lectin 3 \/ CD33, 20 ug","description":"\u003cp\u003eRecognizes a 67kDa glycoprotein, which is identified as CD33. It is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548340486424,"sku":"V5822-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_6de4a9ec-18c9-4e2c-805c-68b2a0cd5b4b.jpg?v=1768278125","url":"https:\/\/danabiosci.com\/products\/nsj-v5822-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}