{"product_id":"nsj-v5596-100ug","title":"Interleukin 18 Antibody \/ IL-18, 100 ug","description":"\u003cp\u003eFour structurally related IL-1 receptor ligands have been described. These include three agonists designated IL-1a, IL-1b and IL-1g\/IL-18 and a specific receptor antagonist, IL-1Ra. IL-1a and IL-1b play critical roles in the regulation of the immune response and inflammation, serving as activators of T and B lymphocytes and NK (natural killer) cells. IL-18 (also referred to as IL-1g) has been shown to augment the secretion of IFN-g from T lymphocytes and increase NK cell activity in spleen cells. IL-18 exhibits 19% and 12% identity with IL-1a and IL-1b respectively over the 12 beta-strands of the beta-trefoil fold domain, which is a signature feature of the IL-1 family. The unusual leader sequence of IL-18 may be analogous to the IL-1b pro-domain which must be cleaved by the serine protease ICE for optimal secretion and biological activity. Originally described as IGIF (IFN-g-inducing factor), IL-18 is induced by mouse liver subsequent to challenge with lipopolysaccharide (LPS).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51548371681560,"sku":"V5596-100UG","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_366cf33f-8938-4e29-b92c-9943850be53a.jpg?v=1768279154","url":"https:\/\/danabiosci.com\/products\/nsj-v5596-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}