{"product_id":"nsj-v5123-20ug","title":"BTBD9 Antibody \/ BTB\/POZ domain-containing protein 9, 20 ug","description":"\u003cp\u003eBTBD9 (BTB\/POZ domain-containing protein 9) is a 612 amino acid protein that contains one BTB\/POZ domain and one BACK (BTB\/Kelch associated) domain. The BTB\/POZ domain mediates homomeric and heteromeric POZPOZ interactions and is common to transcriptional regulators involved in chromatin modeling. In several BTB\/POZ containing proteins, including Bcl-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT\/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. This suggests that BTBD9 may play a role in transcription regulation. Genetic variations in the gene that encodes BTBD9 have been associated with susceptibility to restless legs syndrome type 6 (RLS6), a condition characterized by an uncontrollable urge to move the legs while resting.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548448555288,"sku":"V5123-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_748679ae-f3fc-4951-a840-42478740701b.jpg?v=1768281449","url":"https:\/\/danabiosci.com\/products\/nsj-v5123-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}