{"product_id":"nsj-v4915-20ug","title":"IL-1 beta Antibody \/ IL1B, 20 ug","description":"\u003cp\u003eRecognizes a protein of 17-31kDa, identified as interleukin 1beta. It shows no cross-reaction with interleukin 1alpha. Epitopes of mAb IL1B\/463 and IL1B\/4649 are different and provide a good pair for developing an ELISA. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1\/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2\/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548551446808,"sku":"V4915-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_742517e6-2eb5-4d86-85b7-1596d40a9e1e.jpg?v=1768282393","url":"https:\/\/danabiosci.com\/products\/nsj-v4915-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}