{"product_id":"nsj-v4405-20ug","title":"Recombinant MVP Antibody \/ Major Vault Protein, 20 ug","description":"\u003cp\u003eRecognizes a protein of 104kDa-110kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for \u0026gt;70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548625895704,"sku":"V4405-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_b8aac891-d0b9-40d7-b7c2-cc78d5c17619.jpg?v=1768284712","url":"https:\/\/danabiosci.com\/products\/nsj-v4405-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}