{"product_id":"nsj-v4252-100ug","title":"SHP-1 Antibody \/ PTPN6 \/ PTP1C, 100 ug","description":"\u003cp\u003ePTPN6, which is also designated as SHP-1 and PTP1C, is expressed primarily in hematopoietic cells and characterized by the presence of two SH2 domains N-terminal to the PTP domain. It maps to 12p13, a region commonly involved in leukemia-associated chromosomal abnormalities. SHP-1 plays a role in modulating intracellular signaling for various molecules. In T-cell lymphomas and other malignancies, SHP-1 phosphatase expression is lost, by a thus far undetermined mechanism. Preliminary studies suggest that it may be helpful in differentiating mantle\/marginal zone lymphomas (SHP-1+) from follicular lymphomas (SHP-1 negative).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51548650176792,"sku":"V4252-100UG","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_38913205-d478-46aa-9cf8-e36f346689c2.jpg?v=1768285425","url":"https:\/\/danabiosci.com\/products\/nsj-v4252-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}