{"product_id":"nsj-v3827-20ug","title":"Dnmt3a Antibody, 20 ug","description":"\u003cp\u003eDNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548819652888,"sku":"V3827-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_e1c23d0a-7162-40a2-aeca-62ac772de06b.jpg?v=1768287179","url":"https:\/\/danabiosci.com\/products\/nsj-v3827-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}