{"product_id":"nsj-v3827-100ug","title":"Dnmt3a Antibody, 100 ug","description":"\u003cp\u003eDNMT3A is required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51548819685656,"sku":"V3827-100UG","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_74486242-cc9e-4f15-8106-0a4b030eddb2.jpg?v=1768287181","url":"https:\/\/danabiosci.com\/products\/nsj-v3827-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}