{"product_id":"nsj-v3471ihc-7ml","title":"Recombinant CD8 Antibody (alpha chain) \/ Rabbit Monoclonal, 7 ml","description":"\u003cp\u003eCD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha\/beta) or as a homodimer (CD8 alpha\/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper\/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+\/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma\/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"7 ml","offer_id":51548902031640,"sku":"V3471IHC-7ML","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_f4ee5275-758c-4fd7-a233-64d55c397791.jpg?v=1768288955","url":"https:\/\/danabiosci.com\/products\/nsj-v3471ihc-7ml","provider":"Dana Bioscience","version":"1.0","type":"link"}