{"product_id":"nsj-v3387-20ug","title":"Thymidine Phosphorylase Antibody \/ PD-ECGF, 20 ug","description":"\u003cp\u003eRecognizes a 485 amino acid protein (55 kDa monomer \/ 110 kDa homodimer), identified as platelet-derived endothelial growth factor (PD-ECGF), also called Thymidine Phosphorylase (TP, Tymp) or Gliostatin. In the presence of inorganic orthophosphate, it catalyzes the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. Its enzymatic activity is crucial for angiogenic activity (metabolite is angiogenic). Higher levels of serum TP\/PD-ECGF are observed in cancer patients. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites (e.g. 5 -deoxy-5-fluorouridine to 5-FU). High intra-cellular levels of TP\/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51548917137688,"sku":"V3387-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_7da65f6c-5c78-4f5d-ad4e-bf5e02874e78.jpg?v=1768289267","url":"https:\/\/danabiosci.com\/products\/nsj-v3387-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}