{"product_id":"nsj-v2915-100ug","title":"TYR Antibody Cocktail (Tyrosinase), 100 ug","description":"\u003cp\u003eRecognizes a cluster of proteins between 70-80kDa, identified as Tyrosinase\/TYR. Occasionally a minor band at 55kDa is also detected. This mAb shows no cross-reaction with MAGE-1 and tyrosinase-related protein 1, TRP-1\/gp75. Tyrosinase is a copper-containing metalloglycoprotein that catalyzes several steps in the melanin pigment biosynthetic pathway; the hydroxylation of tyrosine to L-3,4-dihydroxy-phenylalanine (dopa), and the subsequent oxidation of dopa to dopaquinone. Mutations of the tyrosinase gene occur in various forms of albinism. Tyrosinase is one of the targets for cytotoxic T-cell recognition in melanoma patients. Staining of melanomas with this mAb shows tyrosinase in melanotic as well as amelanotic variants. This mAb is a useful marker for melanocytes and melanomas.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549072621848,"sku":"V2915-100UG","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_a5be9798-4efc-43a4-82be-5fee4ce8657a.jpg?v=1768291309","url":"https:\/\/danabiosci.com\/products\/nsj-v2915-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}