{"product_id":"nsj-v2527-20ug","title":"EMI1 Antibody, 20 ug","description":"\u003cp\u003eEarly Mitotic Inhibitor-1 regulates mitosis by inhibiting the anaphase promoting complex\/cyclosome (APC). It is a conserved F box protein containing a zinc-binding region essential for APC inhibition. The protein functions to promote cyclin A accumulation and S phase entry in somatic cells by inhibiting the APC complex. At the G1-S transition, EMI1 is transcriptionally induced by the E2F transcription factor. Overexpression accelerates S-phase entry and can override a G1 block caused by overexpression of Cdh1 or the E2F-inhibitor p105 retinoblastoma protein (pRb). Depleting cells of EMI1 through RNA interference prevents accumulation of cyclin A and inhibits S phase entry.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51549168795928,"sku":"V2527-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_1ca17d3d-23b4-40e4-8e55-96267e5ce649.jpg?v=1768293234","url":"https:\/\/danabiosci.com\/products\/nsj-v2527-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}