{"product_id":"nsj-v2288ihc-7ml","title":"Thymidylate Synthase Antibody, 7 ml","description":"\u003cp\u003eThis antibody is specific for a protein of 36kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"7 ml","offer_id":51549212442904,"sku":"V2288IHC-7ML","price":559.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_ae4b6917-ee96-4a00-8489-9de4272d3974.jpg?v=1768294209","url":"https:\/\/danabiosci.com\/products\/nsj-v2288ihc-7ml","provider":"Dana Bioscience","version":"1.0","type":"link"}