{"product_id":"nsj-v2190-20ug","title":"CD46 Antibody, 20 ug","description":"\u003cp\u003eCD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a co-stimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"20 ug","offer_id":51549227122968,"sku":"V2190-20UG","price":259.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_6f19af78-2e8c-4355-b646-b1a3bc9ef979.jpg?v=1768294508","url":"https:\/\/danabiosci.com\/products\/nsj-v2190-20ug","provider":"Dana Bioscience","version":"1.0","type":"link"}