{"product_id":"nsj-rz1314-100ug","title":"Zebrafish Spi1b Antibody | Pu.1b | Spi1, 100 ug","description":"\u003cp\u003eZebrafish Spi1b, also known as PU.1b, is a transcription factor that belongs to the ETS family of DNA binding proteins. Spi1b plays a critical role in the development of hematopoietic lineages, particularly in the differentiation of myeloid and lymphoid cells. It regulates genes involved in immune cell development, function, and response, making it an essential factor for studying blood formation and immune system regulation during zebrafish embryogenesis.\u003c\/p\u003e\u003cp\u003eZebrafish Spi1b is an ortholog of the human SPI1 protein, also known as PU.1, and shares high sequence and functional conservation. Similar to its human counterpart, Spi1b binds to specific ETS motifs in gene promoters and enhancers to activate or repress target genes. It is particularly important in the early stages of myelopoiesis and is a key regulator of macrophage and neutrophil lineage commitment.\u003c\/p\u003e\u003cp\u003eThe use of a Zebrafish Spi1b antibody allows researchers to examine Spi1b expression and localization in developing blood and immune cells. Such antibodies are essential for applications including western blot, immunohistochemistry, and immunofluorescence, enabling detailed characterization of hematopoietic cell populations. A Zebrafish Spi1b antibody can also be used to investigate transcriptional networks controlling immune development and to study the effects of genetic or chemical perturbations on blood cell formation.\u003c\/p\u003e\u003cp\u003eThere are no known isoforms of zebrafish Spi1b, and its expression is tightly regulated during embryogenesis and hematopoietic stem cell differentiation. Using a high-quality Zebrafish Spi1b antibody, researchers can gain insights into conserved mechanisms of immune regulation that are relevant to both zebrafish and humans.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549534519576,"sku":"RZ1314","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_15877c6f-aedf-441b-aafa-66a2bc0ee153.jpg?v=1768300550","url":"https:\/\/danabiosci.com\/products\/nsj-rz1314-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}