{"product_id":"nsj-rz1246-100ug","title":"Zebrafish N-cadherin Antibody \/ Ncad \/ Cdh2 \/ Cadherin 2, 100 ug","description":"\u003cp\u003eN cadherin, also known as Ncad, cadherin 2 and neural cadherin, is a calcium dependent cell adhesion molecule that plays a critical role in the formation and maintenance of tissue architecture during development. In zebrafish, N cadherin is essential for processes such as gastrulation, neurulation, somite formation, and organ morphogenesis.\u003c\/p\u003e\u003cp\u003eZebrafish N cadherin is the ortholog of the human CDH2 gene, which encodes the same protein. Both zebrafish and human N cadherin are members of the classical cadherin family and share a conserved structure that includes extracellular cadherin repeats, a single transmembrane domain, and a cytoplasmic region that interacts with catenins to link cell adhesion to the actin cytoskeleton.\u003c\/p\u003e\u003cp\u003eIn zebrafish embryos, N cadherin is expressed in the developing nervous system, heart, somites, and other tissues undergoing epithelial to mesenchymal transitions. It mediates homophilic cell-cell adhesion, ensuring coordinated cell movements and stable tissue organization. Loss of N cadherin function in zebrafish results in severe developmental defects, including impaired brain morphogenesis, defective heart formation, and abnormal cell migration.\u003c\/p\u003e\u003cp\u003eDue to its strong evolutionary conservation and fundamental role in cell adhesion and signaling, zebrafish N cadherin is widely used as a model to study developmental biology, tissue engineering, cancer metastasis, and congenital disorders involving cadherin dysfunction.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549544677656,"sku":"RZ1246","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_5f7ba2e8-9210-4108-9fee-b37f94d7a8f3.jpg?v=1768300678","url":"https:\/\/danabiosci.com\/products\/nsj-rz1246-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}