{"product_id":"nsj-rz1243-100ug","title":"Zebrafish Myod1 Antibody \/ Myoblast determination protein 1 \/ Myogenic factor 1, 100 ug","description":"\u003cp\u003eMyod1, also called Myogenic factor 1, Myogenic differentiation 1 and Myoblast determination protein 1, is a master regulatory transcription factor that plays a central role in the specification and differentiation of skeletal muscle. In zebrafish, Myod1 is essential for the commitment of precursor cells to the myogenic lineage during embryonic development and regeneration. It acts by activating the expression of muscle specific genes and by coordinating the transition from cell proliferation to terminal differentiation.\u003c\/p\u003e\u003cp\u003eZebrafish Myod1 is the functional ortholog of human MYOD1. Both proteins belong to the basic helix loop helix family of transcription factors and share a high degree of sequence and functional conservation. Like its human counterpart, zebrafish Myod1 binds to E box elements in the promoters of muscle genes to drive their expression.\u003c\/p\u003e\u003cp\u003eDuring zebrafish development, Myod1 is expressed in the somites and presomitic mesoderm, where it promotes the formation of fast twitch muscle fibers. It works in concert with other myogenic regulators such as Myf5 and Myogenin to establish the muscle differentiation program. Disruption of Myod1 function in zebrafish leads to defects in muscle formation and delayed differentiation of myoblasts.\u003c\/p\u003e\u003cp\u003eBecause of its conserved role in vertebrate myogenesis, zebrafish Myod1 is widely used as a marker of muscle lineage commitment and as a tool in genetic and chemical screening to study muscle development, regeneration, and disease. It also provides a useful model for understanding the regulation of transcriptional networks in myogenic cells.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549544874264,"sku":"RZ1243","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_fcb3b396-4460-4b41-926e-ab23249ce6d3.jpg?v=1768300683","url":"https:\/\/danabiosci.com\/products\/nsj-rz1243-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}