{"product_id":"nsj-rz1208-100ug","title":"Zebrafish Caspase 9 Antibody \/ Casp9, 100 ug","description":"\u003cp\u003eCaspase 9 is a key initiator caspase in the intrinsic (mitochondrial) apoptotic pathway, responsible for activating downstream effector caspases and orchestrating programmed cell death. In zebrafish (Danio rerio), Caspase 9 plays a conserved role in regulating apoptosis during embryonic development, as well as in maintaining tissue homeostasis and responding to cellular stress.\u003c\/p\u003e\u003cp\u003eFollowing mitochondrial outer membrane permeabilization, cytochrome c is released into the cytosol, leading to the formation of the apoptosome complex. Caspase 9 is recruited and activated within this complex, initiating a proteolytic cascade that culminates in the activation of effector caspases such as Caspase 3 and Caspase 7. In zebrafish, casp9 is expressed in multiple tissues during development and is crucial for eliminating damaged, mis-specified, or excess cells.\u003c\/p\u003e\u003cp\u003eZebrafish Caspase 9 is widely used in research on cell death mechanisms, neurodevelopment, cancer biology, and toxicology, providing an in vivo model to study mitochondria-mediated apoptosis and the effects of pro- and anti-apoptotic signals. Due to its high degree of functional conservation with mammalian caspase-9, it serves as a valuable tool for both basic and translational research.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549547069720,"sku":"RZ1208","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_262c50b7-f110-462b-bd8d-99d0c2852bcc.jpg?v=1768300737","url":"https:\/\/danabiosci.com\/products\/nsj-rz1208-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}