{"product_id":"nsj-rz1179-100ug","title":"Zebrafish Luteinizing hormone beta Antibody \/ Lhb, 100 ug","description":"\u003cp\u003eLuteinizing hormone (LH) is a glycoprotein hormone critical for the regulation of reproductive function in vertebrates. It consists of a common alpha subunit and a hormone-specific beta subunit, the latter conferring biological specificity. In zebrafish (Danio rerio), the Lhb gene encodes the beta subunit of LH and plays a key role in the hypothalamic-pituitary-gonadal (HPG) axis.\u003c\/p\u003e\u003cp\u003eZebrafish Lhb is produced by gonadotrope cells in the anterior pituitary and is essential for triggering final oocyte maturation and ovulation in females, as well as steroidogenesis and spermatogenesis in males. Its expression is tightly regulated by gonadotropin-releasing hormone (GnRH) and modulated by sex steroids through feedback mechanisms.\u003c\/p\u003e\u003cp\u003eThe zebrafish model has been instrumental in dissecting the molecular and developmental regulation of lhb expression. Notably, Lhb mRNA becomes detectable during larval stages and increases during sexual maturation. Functional studies using gene knockout and reporter lines have demonstrated that Lhb is indispensable for fertility, and its disruption results in reproductive failure.\u003c\/p\u003e\u003cp\u003eDue to its conserved structure and function, zebrafish Lhb serves as a valuable model for studying reproductive endocrinology, pituitary cell differentiation, and hormone signaling pathways in vertebrates.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549552410904,"sku":"RZ1179","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_91f2e485-35a1-4256-81b2-325af0ab14a4.jpg?v=1768300785","url":"https:\/\/danabiosci.com\/products\/nsj-rz1179-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}