{"product_id":"nsj-rz1163-100ug","title":"Zebrafish Hsp60 Antibody \/ Hspd1, 100 ug","description":"\u003cp\u003eHSP60 is a member of the chaperonin class of protein factors, which include the Escherichia coli groEL protein and the Rubisco subunit-binding protein of chloroplasts. It acts as a costimulator of human regulatory CD4-positive\/CD25 -positive T cells, which inhibit lymphoproliferation and IFNG and TNF secretion by CD4-positive and CD8-positive T cells. HSP60 enhances Treg activity via TLR2, leading to activation of an intracellular signaling cascade that included p38, as well as inhibition of ERK phosphorylation. Suppression of target T cells is mediated by both cell-to-cell contact and by secretion of TGFB and IL10, and it leads to downregulation of ERK, NFKB, and TBET expression. The self-molecule HSP60 can downregulate adaptive immune responses by upregulating Tregs through TLR2 signaling.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549555982616,"sku":"RZ1163","price":539.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_fdd4d15b-3fe6-4d8d-be22-e2ccb2ccfd0d.jpg?v=1768300807","url":"https:\/\/danabiosci.com\/products\/nsj-rz1163-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}