{"product_id":"nsj-rq8617-100ug","title":"Pellino 2 Antibody \/ PELI2, 100 ug","description":"\u003cp\u003eProtein pellino homolog 2 is a protein that in humans is encoded by the PELI2 gene. PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549650977048,"sku":"RQ8617","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_451fca20-708b-4ab7-8d66-da06a2caebed.jpg?v=1768301575","url":"https:\/\/danabiosci.com\/products\/nsj-rq8617-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}