{"product_id":"nsj-rq8209-100ug","title":"PA26 Antibody \/ SESN1 \/ SEST1 \/ Sestrin 1, 100 ug","description":"\u003cp\u003eSestrin 1, also known as p53-regulated protein PA26 and SEST1, is a protein that in humans is encoded by the SESN1 gene. This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549706813720,"sku":"RQ8209","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_244c53b0-b737-4d92-8b0a-88f27bc69c43.jpg?v=1768302200","url":"https:\/\/danabiosci.com\/products\/nsj-rq8209-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}