{"product_id":"nsj-rq7442-100ug","title":"TGIF1 Antibody \/ 5-TG-3-interacting factor 1 \/ TGIF, 100 ug","description":"\u003cp\u003eHomeobox protein TGIF1 is a protein that in humans is encoded by the TGIF1 gene. The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549916954904,"sku":"RQ7442","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_893cb850-5511-4029-80e4-f4bd7cc1f931.jpg?v=1768303401","url":"https:\/\/danabiosci.com\/products\/nsj-rq7442-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}