{"product_id":"nsj-rq7321-100ug","title":"DEP1 Antibody \/ Density-enhanced phosphatase 1 \/ PTPRJ, 100 ug","description":"\u003cp\u003eReceptor-type tyrosine-protein phosphatase eta, also called Density-enhanced phosphatase 1 (DEP1) and CD148, is an enzyme that in humans is encoded by the PTPRJ gene. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes, including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This protein is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 and Linker for Activation of T Cells. This protein can also dephosphorylate the PDGF beta receptor, and may be involved in UV-induced signal transduction. Multiple transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51549929734424,"sku":"RQ7321","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_df84dd97-b530-46c3-8513-5ef2af58b949.jpg?v=1768303589","url":"https:\/\/danabiosci.com\/products\/nsj-rq7321-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}