{"product_id":"nsj-rq6971-100ug","title":"DAB2 Antibody \/ Disabled homolog 2, 100 ug","description":"\u003cp\u003eDisabled homolog 2 is a protein that in humans is encoded by the DAB2 gene. This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor\/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550001692952,"sku":"RQ6971","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_e74b5e84-5655-41e1-883e-858381774dc7.jpg?v=1768304092","url":"https:\/\/danabiosci.com\/products\/nsj-rq6971-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}