{"product_id":"nsj-rq6339-100ug","title":"SMAD7 Antibody \/ MADH7, 100 ug","description":"\u003cp\u003eMothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene. The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550061494552,"sku":"RQ6339","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_6bbaad3f-425d-47a0-9ff7-a3897ade1f50.jpg?v=1768305021","url":"https:\/\/danabiosci.com\/products\/nsj-rq6339-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}