{"product_id":"nsj-rq6121-100ug","title":"Apc5 Antibody \/ Anaphase-promoting complex subunit 5, 100 ug","description":"\u003cp\u003eAnaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene. This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex\/cyclosome (APC\/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC\/C and for the interaction of APC\/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550078271768,"sku":"RQ6121","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_9f42c128-3085-4e84-b986-171d9e9a3225.jpg?v=1768305339","url":"https:\/\/danabiosci.com\/products\/nsj-rq6121-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}