{"product_id":"nsj-rq5573-100ug","title":"DBH Antibody \/ Dopamine beta Hydroxylase, 100 ug","description":"\u003cp\u003eDopamine beta-hydroxylase (DBH), also known as dopamine beta-monooxygenase, is an enzyme (EC1.14.17.1) that in humans is encoded by the DBH gene. Dopamine beta-hydroxylase catalyzes the chemical reaction. It is mapped to 9q34.2. The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550123065624,"sku":"RQ5573","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_6c0ca4b4-ec0b-4910-aa88-3c0110790a02.jpg?v=1768306270","url":"https:\/\/danabiosci.com\/products\/nsj-rq5573-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}