{"product_id":"nsj-rq5507-100ug","title":"IRS1 Antibody \/ Insulin receptor substrate 1, 100 ug","description":"\u003cp\u003eInsulin receptor substrate 1 (IRS-1) is a signalling adapter protein that in humans is encoded by the IRS1 gene. It is mapped to 2q36.3. This gene exhibited no intrinsic enzyme activity, and it can serve as a docking protein involved in binding and activating other signal transduction molecules after being phosphorylated on tyrosine by insulin receptor kinase. IRS1 plays a key role in transmitting signals from the insulin and insulin-like growth factor-1(IGF-1) receptors to intracellular pathways PI3K\/Akt and Erk MAP kinase pathways. IRS1 also has important biological function for both metabolic and mitogenic(growth promoting) pathways. In addition to those, IRS1 is a key regulator of PI3K within malignant cells.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550126309656,"sku":"RQ5507","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_65e874ab-01b3-4a3c-8444-8c07c1cc83d3.jpg?v=1768306384","url":"https:\/\/danabiosci.com\/products\/nsj-rq5507-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}