{"product_id":"nsj-rq5289-100ul","title":"Cleaved PARP Antibody, 100 ul","description":"\u003cp\u003eThe main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. [Wiki]\u003cbr\u003e\u003cbr\u003eCleavage of PARP, by enzymes such as caspases or cathepsins, typically inactivates PARP. While in vitro cleavage by caspase occurs throughout the caspase family, preliminary data suggest that caspase-3 and caspase-7 are responsible for in vivo cleavage. Cleavage occurs at aspartic acid 214 and glycine 215, separating PARP into a 24kDA and 89kDA segment. The smaller moiety includes the zinc finger motif requisite in DNA binding. The 89 kDa fragment includes the auto-modification domain and catalytic domain. [Wiki]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51550136303896,"sku":"RQ5289","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_76d91e02-6c13-42ad-abfe-b5dbd285b7e2.jpg?v=1768306651","url":"https:\/\/danabiosci.com\/products\/nsj-rq5289-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}