{"product_id":"nsj-rq4503-100ul","title":"Phospho-Histone H2AX Antibody (pS139), 100 ul","description":"\u003cp\u003eVariant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. [UniProt]\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ul","offer_id":51550173593880,"sku":"RQ4503","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_d331559b-f3e5-46dc-9381-3a17a71622bb.jpg?v=1768307730","url":"https:\/\/danabiosci.com\/products\/nsj-rq4503-100ul","provider":"Dana Bioscience","version":"1.0","type":"link"}