{"product_id":"nsj-rq4235-100ug","title":"MDC1 Antibody, 100 ug","description":"\u003cp\u003eMediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene. The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2\/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550184505624,"sku":"RQ4235","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_af2fb950-f9e4-498a-8647-5dba8e8ae393.jpg?v=1768308031","url":"https:\/\/danabiosci.com\/products\/nsj-rq4235-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}