{"product_id":"nsj-rq4016-100ug","title":"gp91phox Antibody \/ NOX2 \/ CYBB, 100 ug","description":"\u003cp\u003eNOX2 (NADPH Oxidase 2), also called CYBB (Cytochrome b(-245), beta subunit), p91-PHOX or GP91-1, is a human gene encoding a glycoprotein. NOX2 is an essential component of phagocytic NADPH-oxidase, a membrane-bound enzyme complex that generates large quantities of microbicidal superoxide and other oxidants upon activation. It is mapped on Xp11.4. NOX2 assembled on DC phagosomes in a gp91-phox subunit-dependent manner, and that reactive oxygen species were produced in a more sustained manner in immature DC phagosomes than in macrophage phagosomes. As a major player in innate immune responses in neutrophils, NOX2 is also involved in adaptive immunity through its activity in DCs. In heart cells, physiologic stretch rapidly activates reduced-form NOX2 to produce reactive oxygen species (ROS) in a process dependent on microtubules (X-ROS signaling).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550192009496,"sku":"RQ4016","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_c3e093f6-7022-4cb3-882a-960151861cbd.jpg?v=1768308312","url":"https:\/\/danabiosci.com\/products\/nsj-rq4016-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}