{"product_id":"nsj-r32618-100ug","title":"CD212 Antibody \/ IL12RB1, 100 ug","description":"\u003cp\u003eIL12RB1, mapped to 19p13.11, is also known as CD212. The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukin 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. And this protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550400676120,"sku":"R32618","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_153fe627-8b06-4d8d-8fb0-b7ffabc0ca5d.jpg?v=1768313146","url":"https:\/\/danabiosci.com\/products\/nsj-r32618-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}