{"product_id":"nsj-r32542-100ug","title":"KRIT1 Antibody \/ CCM1, 100 ug","description":"\u003cp\u003eKrev interaction trapped protein 1 is a protein that in humans is encoded by the CCM1 gene. This gene encodes a protein containing four ankyrin repeats, a band 4.1\/ezrin\/radixin\/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550404870424,"sku":"R32542","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_bf2f270d-0867-42ac-96d5-ef09b8a1d76b.jpg?v=1768313250","url":"https:\/\/danabiosci.com\/products\/nsj-r32542-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}