{"product_id":"nsj-r32359-100ug","title":"DNA polymerase eta Antibody \/ POLH, 100 ug","description":"\u003cp\u003eDNA polymerase eta (POLH), is a protein that in humans is encoded by the POLH gene. This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550414471448,"sku":"R32359","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_c3b74f60-8d15-46f7-aaa9-c64b87476f04.jpg?v=1768313538","url":"https:\/\/danabiosci.com\/products\/nsj-r32359-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}