{"product_id":"nsj-r32307-100ug","title":"ITCH Antibody \/ AIF4, 100 ug","description":"\u003cp\u003eITCH is an ubiquitin-conjugating enzyme. This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550417256728,"sku":"R32307","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_8b91bc2b-65f1-405c-8aa3-d43ba9fd3c44.jpg?v=1768313614","url":"https:\/\/danabiosci.com\/products\/nsj-r32307-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}