{"product_id":"nsj-r32238-100ug","title":"SMAD Antibody [SMAD1-5], 100 ug","description":"\u003cp\u003eSMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs\/CoSMAD, act as transcription factors that regulate the expression of certain genes. It was concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-beta superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550422139160,"sku":"R32238","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_cade4947-9e4c-42c8-86c0-a2ffe81db006.jpg?v=1768313711","url":"https:\/\/danabiosci.com\/products\/nsj-r32238-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}