{"product_id":"nsj-r31802-100ug","title":"AIM2 Antibody, 100 ug","description":"\u003cp\u003eAbsent In Melanoma 2 is a protein that in humans is encoded by the AIM2 gene. AIM2 is a member of the Ifi202\/IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. Though there has been virtually no biochemistry performed, a model based on cell-based or in vivo experiments has led to the current model of how AIM2 triggers the inflammasome. The C-terminal HIN domain binds double stranded DNA (either viral, bacterial, or even host) and acts as a cytosolic dsDNA sensor. This leads to the oligomerization of the inflammasome complex. The N-terminal pyrin domain of AIM2 interacts with the pyrin domain of another protein ASC (or Apoptosis-associated Speck-like protein containing a caspase activation and recruitment domain). ASC also contains a CARD domain (caspase activation and recruitment domain), that recruits procaspase-1 to the complex. This leads to the autoactivation of caspase-1, an enzyme that processes proinflammatory cytokines (IL-1b and IL-18).\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550444519704,"sku":"R31802","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_c1caa72b-6de0-4459-8991-602bf93820b3.jpg?v=1768314352","url":"https:\/\/danabiosci.com\/products\/nsj-r31802-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}