{"product_id":"nsj-r31578-100ug","title":"SIRT1 Antibody, 100 ug","description":"\u003cp\u003eSirtuin 1, also known as SIR2L1, is a protein that in humans is encoded by the SIRT1 gene. Sirtuin 1 is a member of the sirtuin family of proteins, homologs of the Sir2 gene in S. cerevisiae. Family members are characterized by a sirtuin core domain and grouped into four classes. Sirtuin 1 is downregulated in cells that have high insulin resistance and inducing its expression increases insulin sensitivity, suggesting the molecule is associated with improving insulin sensitivity. Furthermore, SIRT1 was shown to de-acetylate and affect the activity of both members of the PGC1-alpha\/ERR-alpha complex, which are essential metabolic regulatory transcription factors.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550456807704,"sku":"R31578","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_cadfead5-9100-49c8-9475-99705e27c2d3.jpg?v=1768314662","url":"https:\/\/danabiosci.com\/products\/nsj-r31578-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}