{"product_id":"nsj-r31125-100ug","title":"BMPR1B Antibody, 100 ug","description":"\u003cp\u003eBone Morphogenetic Protein Receptor Type IB, also known as ALK6, is a protein which in humans is encoded by the BMPR1B gene. It is a member of the bone morphogenetic protein(BMP) receptor family of transmembrane serine\/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine(threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. By analysis of a monochromosome hybrid mapping panel and by FISH, Astrom et al.(1999) mapped the BMPR1B gene to chromosome 4q22-q24. Ide et al.(1997) compared BMP receptor expression in normal and cancerous prostate tissues. While BMPR1A and BMPR2 were expressed at similar levels in all prostate tissues, BMPR1B was expressed at a significantly reduced level in cancerous prostate tissue.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550480826648,"sku":"R31125","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_63bbec14-2588-49f9-bc3b-eaeda32bcb67.jpg?v=1768315206","url":"https:\/\/danabiosci.com\/products\/nsj-r31125-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}