{"product_id":"nsj-r31020-100ug","title":"MALT1 Antibody \/ Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 100 ug","description":"\u003cp\u003eMucosa-associated lymphoid tissue lymphoma translocation protein 1, also called MLT or Paracaspase, is a protein that in humans is encoded by the MALT1 gene. This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3(also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. Dierlamm et al.(1999) and Akagi et al.(1999) mapped the gene to chromosome 18q21. Using mouse models, Ruland et al.(2003) demonstrated that MALT1 is essential for T-cell activation, proliferation, and IL2 production in response to T-cell receptor ligation and strictly required for signal-specific NF-kappa-B(NFKB) activation induced by the T-cell receptor but not TNF-alpha or IL1 signaling. MALT1 operates downstream of BCL10, controls the catalytic activity of the canonical I-kappa-B kinase complex, and regulates the signaling of JNK and p38 MAP kinases.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550486233368,"sku":"R31020","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_309f1854-fb03-4412-b18d-cb148defd188.jpg?v=1768315317","url":"https:\/\/danabiosci.com\/products\/nsj-r31020-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}