{"product_id":"nsj-r30968-100ug","title":"ABCG2 Antibody (BCRP), 100 ug","description":"\u003cp\u003eATP-binding cassette, subfamily g, member 2, also known as ABCP, BCRP or MRX,is aprotein that in humans is encoded by the ABCG2gene. Thegene encodes a membrane transporter belonging to the ATP-binding cassette(ABC) superfamily of membrane transporters, which are involved in the trafficking of biologic molecules across cell membranes.Theprotein is also a high capacity transporter for uric acid excretion in the kidney, liver, and gut. The ABCG2 gene is mapped on 4q22.1. In vitro assays of isolated membrane preparations revealed a high-capacity, vanadate-sensitive ATPase activity associated withABCG2expression that was stimulated by compounds known to be transported by this protein. Ozvegy et al.(2001)concluded thatthe proteinis likely functioning as a homodimer or homooligomer in this expression system since it is unlikely that putative Sf9 transport partners would be overexpressed at similarly high levels.Abcg2transports pheophorbide-a, which occurs in various plant-derived foods and food supplements and is highly efficient in limiting its uptake from ingested food.ABCG2is a major factor in the concentrative transfer of drugs, carcinogens, and dietary toxins to the milk of mice, cows, and humans.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550488035608,"sku":"R30968","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_eea9e61b-ce19-41a8-9a59-10edaa61e63a.jpg?v=1768315368","url":"https:\/\/danabiosci.com\/products\/nsj-r30968-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}