{"product_id":"nsj-r30907-100ug","title":"Daxx Antibody \/ Death-associated protein 6, 100 ug","description":"\u003cp\u003eDeath-domain associated protein, also known as DAP6 (Death-associated protein 6), Daxx and BING2, was first discovered through its cytoplasmic interaction with the classical death receptor Fas. The gene encodes a 740-amino acid polypeptide containing a nuclear localization signal. Functional analyses by Yang et al.(1997) demonstrated that Daxx binds to the Fas death domain and enhances Fas-mediated apoptosis. The authors suggested that DAXX and FADD define 2 distinct apoptotic pathways downstream of Fas. The gene is mapped to human chromosome 6p21.3 by somatic cell hybrid panels and fluorescence in situ hybridization, a region containing the HLA and putative autoimmune disease genes. MSP58 overexpression relieved DAXX-mediated transcriptional repression. Immunoprecipitation and Western blot analysis with DAXX mutants showed that the N terminus of the protein interacts with the C terminus of DMAP. Transient expression of DAXX or DMAP1 caused repression of glucocorticoid receptor-mediated transcription.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550491410712,"sku":"R30907","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_bdfb7fff-4c40-40dc-ab24-8e51aae38a45.jpg?v=1768315446","url":"https:\/\/danabiosci.com\/products\/nsj-r30907-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}