{"product_id":"nsj-r30765-100ug","title":"PI3K Antibody (p85 beta), 100 ug","description":"\u003cp\u003ePhosphatidylinositol 3-kinase regulatory subunit 2, also called p85-Beta, PIK3R2 and PIK3, is an enzyme that in humans is encoded by the PIK3R2 gene. The NS1 protein from various influenza strains bind p85-beta, but not p85-alpha. Binding of p85-beta and activation of PI3K required tyr89 of NS1, and mutant viruses expressing NS1 with a tyr89-to-phe substitution grew more slowly in cell culture than wildtype viruses. Using mouse embryonic fibroblasts, Park et al. showed that, in addition to regulating PI3K function, p85-alpha\/beta regulated the function of Xbp1s, a transcription factor that orchestrates the unfolded protein response (UPR) following endoplasmic reticulum (ER) stress. Overexpression of the protein in livers of ob\/ob mice increased glucose tolerance and reduced blood glucose concentrations.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550497112344,"sku":"R30765","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_50a94acc-71c6-48c7-a8d9-93d67023a242.jpg?v=1768315624","url":"https:\/\/danabiosci.com\/products\/nsj-r30765-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}