{"product_id":"nsj-r30745-100ug","title":"MyD88 Antibody, 100 ug","description":"\u003cp\u003eMyeloid differentiation primary response gene 88 is a protein that in humans is encoded by the MYD88 gene. MyD88 is a key downstream adapter for most Toll-like receptors (TLRs) and interleukin-1 receptors(IL1Rs). It a cytosolic adapter protein that plays a central role in the innate and adaptive immune response. This protein functions as an essential signal transducer in the interleukin-1 and\u003ca href=\"..\/tlr-toll-like-receptor-antibodies.html\"\u003eToll-like receptor\u003c\/a\u003esignaling pathways. Qverexpression causes an increase in the level of transcription from the interleukin-8 promoter. The C-terminal domain of the protein has significant sequence similarity to the cytoplasmic domain of IL1RAP. Inhibiting the IL1R-MyD88 pathway in vivo could block the damage from acute inflammation that occurs in response to sterile cell death, and do so in a way that might not compromise tissue repair or host defense against pathogens.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550498193688,"sku":"R30745","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_60f66cd7-7ce0-4287-9a65-bdb17c35e4c6.jpg?v=1768315646","url":"https:\/\/danabiosci.com\/products\/nsj-r30745-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}