{"product_id":"nsj-r30724-100ug","title":"Ku80 Antibody \/ XRCC5, 100 ug","description":"\u003cp\u003eXRCC5 (X-ray Repair, Complementing Defective, In Chinese Hamster, 5), also known as Ku80 or Ku86, is a protein that in humans, is encoded by the XRCC5 gene. The XRCC5 gene encodes the 80-kD subunit of the Ku autoantigen, a heterodimer which contributes to genomic integrity through its ability to bind DNA double-strand breaks and facilitate repair by the nonhomologous end joining(NHEJ) pathway. Human colon cancer cells heterozygous for Ku80 are haploinsufficient with an increase in polyploid cells, a reduction in cell proliferation, elevated p53 levels, and a slight hypersensitivity to ionizing radiation. Functional inactivation of the second Ku80 allele results in cells with a drastically reduced doubling time. The locus is essential in human somatic tissue culture cells by experiments demonstration. A rare microsatellite polymorphism in the protein is associated with cancer in patients of varying radiosensitivity.\u003c\/p\u003e","brand":"NSJ Bioreagents","offers":[{"title":"100 ug","offer_id":51550498914584,"sku":"R30724","price":449.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0590\/5652\/1400\/files\/get_image_e2f87cd2-d16d-41ec-8427-de3e6aee41b9.jpg?v=1768315672","url":"https:\/\/danabiosci.com\/products\/nsj-r30724-100ug","provider":"Dana Bioscience","version":"1.0","type":"link"}